|
Symbol Name ID |
Itga2b
integrin alpha 2b MGI:96601 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Abnormal bleeding |
Epistaxis |
Spontaneous, recurrent epistaxis |
Excessive bleeding from superficial cuts |
Gingival bleeding |
Gastrointestinal hemorrhage |
Intracranial hemorrhage |
Subdural hemorrhage |
Joint hemorrhage |
Menorrhagia |
Persistent bleeding after trauma |
Prolonged bleeding after dental extraction |
Prolonged bleeding after surgery |
Prolonged bleeding following circumcision |
Prolonged bleeding time |
Bruising susceptibility |
Purpura |
Ecchymosis |
Petechiae |
Spontaneous hematomas |
Abnormal megakaryocyte morphology |
Increased megakaryocyte colony forming unit count |
Anemia |
Anemia of inadequate production |
Poikilocytosis |
Acanthocytosis |
Leukocytosis |
Reduced factor VIII activity |
Impaired ristocetin-induced platelet aggregation |
Reduced quantity of Von Willebrand factor |
Prolonged whole-blood clotting time |
Impaired platelet aggregation |
Impaired ADP-induced platelet aggregation |
Impaired arachidonic acid-induced platelet aggregation |
Impaired collagen-induced platelet aggregation |
Impaired collagen-related peptide-induced platelet aggregation |
Impaired epinephrine-induced platelet aggregation |
Impaired thrombin-induced platelet aggregation |
Impaired thromboxane A2 agonist-induced platelet aggregation |
Decreased platelet glycoprotein IIb-IIIa |
Impaired clot retraction |
Abnormal platelet count |
Thrombocytopenia |
Congenital thrombocytopenia |
Intermittent thrombocytopenia |
Macrothrombocytopenia |
Abnormal platelet shape |
Abnormal platelet volume |
Decreased mean platelet volume |
Giant platelets |
Platelet anisocytosis |
| Disease(s) Associated with ITGA2B | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Glanzmann's thrombasthenia | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| platelet-type bleeding disorder 16 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| thrombocytopenia | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| von Willebrand's disease 1 |
| Mouse Phenotypes | abnormal embryonic hematopoiesis |
enlarged spleen |
abnormal definitive hematopoiesis |
anemia |
decreased erythrocyte cell number |
abnormal platelet alpha-granule morphology |
thrombocytopenia |
increased hematopoietic stem cell number |
abnormal platelet physiology |
abnormal platelet activation |
abnormal platelet aggregation |
decreased platelet aggregation |
|
| Availability | Mouse Genotype | ||||||||||||
| Itga2btm1(GFP/cre)Emam/Itga2btm1(GFP/cre)Emam | |||||||||||||
| Itga2btm1Tlr/Itga2btm1Tlr | |||||||||||||
| Itga2btm1Graf/Itga2b+ | |||||||||||||
| Itga2btm1Tlr/Itga2b+ | |||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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